From North Campus to South Campus, take Millersport Highway South (Route 263) to Bailey Avenue (Route 62). Angle left onto Bailey and turn right on Michael Road into South Campus.

From North Campus to Downtown Campus, take Millersport Highway South (Route 263) to I-290. Merge onto I-90 West via exit 51-61 toward Erie. At exit 51, take Route 33 West (Kensington Expressway) for approximately 7 miles. Note the sign for the "Buffalo Niagara Medical Campus" and take the Locust Street exit, proceeding straight. Turn right onto Ellicott Street. The Downtown Campus is at the corner of Ellicott and Virginia Streets. The total distance is approximately 12 miles.

From South Campus to North Campus, take Bailey Avenue and then follow signs to Millersport Highway (Route 263). From Millersport, take the Flint Loop exit. At the intersection of John James Audubon Parkway and Flint Road, take a left onto Flint Road.

Take Main Street south toward downtown Buffalo (approx. 5 miles). Turn left at Virginia Street and left again at Ellicott Street.

Start out going north on Ellicott Street toward Virginia Street. Turn right onto Virginia Street. Turn right onto Harriet Tubman Way/Michigan Avenue. Take a sharp left onto Cherry Street. Merge onto Route 33 East (Kensington Expressway). Merge onto the I-90 East to the I-290 West (toward Niagara Falls) and proceed until Exit 5B (Millersport Highway, Route 263). Get off exit and merge into traffic. Go through first light (Marriott is on your left) and merge into right lane. Enter campus at the Flint Road exit. The total distance is approximately 12 miles.

Take Ellicott Street north. Turn left on North Street and then right onto Main Street. Take Main Street northwards away from downtown Buffalo for approximately five miles. Enter the South Campus at the Main Street entrance.